Diastereoselective 1,3-dipolar cycloaddition of pyrylium ylides with chiral enamides.
نویسندگان
چکیده
Chiral enamides 5f-i were found to react with pyrylium ylides to give cycloadducts 6d-i in good yields with an excellent level of stereoselectivity. The chiral auxiliary was successfully removed on hydrogenolysis of compound 6f in continuous flow (H-Cube) resulting in the first asymmetric synthesis of complex amine 8.
منابع مشابه
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 21 شماره
صفحات -
تاریخ انتشار 2012